Nonsteroidal anti-inflammatory drug (NSAIDs) are used to treat pain and fever. They are usually purchased over the counter (OTC) and require a prescription. For example, aspirin, Ibuprofen (Advil, Motrin) and Naproxen (Aleve, Naprosyn). They are the preferred choice for headaches or temporary muscle pain, but their combination with methylprednisolone is not ideal.

Both Nonsteroidal anti-inflammatory drug and methylprednisolone are bad for the stomach. They can cause stomach discomfort and nausea. In more severe cases, both drugs increase the risk of gastric bleeding and ulcers. Putting them together will increase these risks.

If possible, try to avoid taking Nonsteroidal anti-inflammatory drug and methylprednisolone at the same time. If you need painkillers when taking methylprednisolone, your healthcare provider may recommend that you use Paracetamol (Tylenol) instead. It is milder to the stomach than NSAIDs.

Corticosteroid like methylprednisolone can raise your blood sugar levels. This makes it harder for diabetes drugs like Metformin to work. When diabetes drugs do not work, you are more likely to experience hyperglycemia.

If you take these medications simultaneously, your healthcare provider may suggest that you check your blood sugar more frequently at home. Be sure to pay attention to signs of high blood sugar, such as thirst and frequent urination.

Ketoconazole is a prescription drug for the treatment of fungal infections. But it can also prevent the breakdown (metabolism) of methylprednisolone. This may cause methylprednisolone to stay in your body for a longer time, thereby increasing the risk of side effects.

It is best to avoid taking these medications simultaneously. This will help prevent the side effects of methylprednisolone, such as new or worsening:
Swelling (edema)
insomnia
Stimulation to the stomach
Changes in mental health
hypertension
Weaker bones

If you need to take these medications simultaneously, your healthcare provider may need to reduce your dose of methylprednisolone for safety purposes.

Phenytoin (Phenytoin, Phenytoin) and Phenobarbital are drugs for the treatment of certain types of Seizure. They can also reduce the amount of methylprednisolone in the body by allowing it to leave your system faster than normal. This may reduce its effectiveness.

Your healthcare provider may closely monitor you if you take any of these drugs with methylprednisolone (what is methylprednisolone). Your dosage may also need to be increased to achieve the full benefits of the medication.